Louisville was settled in 1778 at the confluence of the Ohio River and Beargrass Creek. It was settled there because of the Falls of the Ohio and because Beargrass Creek was a convenient stopping place just east of the treacherous Falls.
In the years since, we've dammed (damned?) the river so that it is more navigable and “safe.” We've moved Beargrass Creek away from the very center of downtown to a point a little east of downtown and more “convenient.” We have also encased a good portion of Beargrass in a concrete channel and turned it into a sewer, also for safety and convenience.
Or, to borrow a line from John Prine's song, Paradise:
They dug for their coal [straightened the creeks, dammed the rivers, etc],
'til the land was forsaken,
then they wrote it all down as the progress of man...
That progress will be the death of us, yet.